Related Experiment Video

Updated: May 3, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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Protein methylation and interaction with the antiproliferative gene, BTG2/TIS21/Pc3

Woon Ki Paik1, Sangduk Kim, In Kyoung Lim

  • 1Temple University School of Medicine, 3500 N Broad St, Philadelphia, PA 19140, USA. sdkim7818@temple.edu.

Yonsei Medical Journal
|February 18, 2014
PubMed

Insights

Protein methylation research has advanced significantly in the past 15 years. This review covers early discoveries and the role of protein methylation in the antiproliferative gene BTG2/TIS21/PC3.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Epigenetics

Background:

  • Protein methylation is a crucial post-translational modification.
  • Recent years have seen a resurgence in research interest and progress in this field.
  • Understanding protein methylation is key to deciphering complex cellular processes.

Observation:

  • The antiproliferative gene BTG2/TIS21/PC3 is a focus of current research.
  • Early discoveries laid the groundwork for understanding protein methylation.
  • This review synthesizes existing knowledge on BTG2/TIS21/PC3 methylation.

Findings:

  • Protein methylation influences the biological functions of BTG2/TIS21/PC3.
  • Specific methylation sites on BTG2/TIS21/PC3 impact its antiproliferative activity.
  • The review details the interplay between methylation and gene function.

Implications:

  • Insights into BTG2/TIS21/PC3 methylation can inform cancer research.
  • Understanding this epigenetic mechanism may reveal new therapeutic targets.
  • Further research into protein methylation holds promise for various biological applications.
Keywords:
APRO (antiproliferative) genesBTG2 (B-cell translocation gene 2)PKMTPRMTProtein methylationTIS21 (TPA-inducible sequences 21)protein methyltransferases

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