Descriptive study of clinical profile and benefit of therapy in childhood hypercalciuria

Area of Science:

• Pediatric Nephrology
• Clinical Chemistry

Background:

• Hypercalciuria is a condition characterized by elevated calcium levels in the urine.
• It can affect children and may be associated with various clinical symptoms and potential complications.

Purpose of the Study:

• To define the clinical profile and outcomes of hypercalciuria in pediatric patients.
• To evaluate the effectiveness of random urinary calcium/creatinine ratio for screening and monitoring treatment response.

Main Methods:

• Analysis of clinical, biochemical, and ultrasonographic data from 91 children with hypercalciuria.
• Assessment of treatment outcomes, primarily with thiazide diuretics.

Main Results:

• Hypercalciuria was most prevalent in children aged 1-5 years (39.6%).
• Hematuria was the most common presenting symptom.
• Random urinary calcium/creatinine ratio demonstrated utility in screening and assessing therapeutic benefits.
• Thiazide treatment led to a good response and favorable outcomes in the majority of patients.

Conclusions:

• Hypercalciuria in children has a distinct clinical profile, with hematuria being a frequent sign.
• The random urinary calcium/creatinine ratio is a valuable tool for managing pediatric hypercalciuria.
• Thiazide therapy is an effective treatment option, yielding positive long-term outcomes.