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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
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Adenoviruses associated with acute diarrhea in children in Beijing, China

Liying Liu1, Yuan Qian1, You Zhang1

  • 1Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.

Plos One
|February 18, 2014
PubMed

Insights

Adenovirus is a significant cause of diarrhea in hospitalized children, with higher rates in hospital-acquired diarrhea (HAD) compared to community-acquired diarrhea (CAD). Non-enteric adenoviruses, particularly type 31, play a notable role in pediatric diarrheal illness.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Epidemiology

Background:

  • Adenoviruses are known causes of community-acquired diarrhea (CAD) in children.
  • The role of adenoviruses in hospital-acquired diarrhea (HAD) remains less understood.
  • Understanding adenovirus prevalence in different pediatric diarrhea settings is crucial for infection control.

Purpose of the Study:

  • To investigate the prevalence and characteristics of adenovirus infections in children with community-acquired diarrhea (CAD) and hospital-acquired diarrhea (HAD).
  • To compare adenovirus detection rates between hospitalized and outpatient pediatric diarrhea cases.
  • To identify specific adenovirus serotypes associated with pediatric diarrhea.

Main Methods:

  • Prospective study of 2233 children with diarrhea from 2011-2012.
  • Adenovirus detection in stool specimens using Polymerase Chain Reaction (PCR).
  • Serotyping and phylogenetic analysis of detected adenoviruses, with statistical analysis using SPSS software.

Main Results:

  • Adenovirus was detected in 9.8% of all diarrheal cases (219/2233).
  • Adenovirus prevalence was significantly higher in hospital-acquired diarrhea (HAD) (13.8%) compared to inpatient community-acquired diarrhea (IP-CAD) (9.3%) and outpatient community-acquired diarrhea (OP-CAD) (8.1%).
  • Adenovirus serotype 41 was most common (41.6%), but non-enteric types, including adenovirus 31 (19.7%), were also significant contributors to pediatric diarrhea.

Conclusions:

  • Adenoviruses are important pathogens in both community-acquired and hospital-acquired diarrhea among children.
  • Hospital-acquired diarrhea in children shows a higher incidence of adenovirus infection.
  • Both enteric and non-enteric adenoviruses, including adenovirus 31, are implicated in pediatric diarrheal diseases, necessitating broader diagnostic considerations.

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