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Disturbances of platelet function in patients with multiple myeloma
E Czestochowska1, W Tymiński, J Górski
1IV Clinic of Internal Medicine, Medical Academy in Gdańsk, Poland.
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1987
Summary
Multiple myeloma patients with high immunoglobulin levels often experience platelet dysfunction. Treatments reducing these proteins can restore normal platelet function, indicating M protein
Area of Science:
- Hematology
- Oncology
- Clinical Chemistry
Background:
- Multiple myeloma is a plasma cell malignancy.
- Coagulation disturbances, particularly platelet dysfunction, are observed in some patients.
- Hyperproteinemia and high immunoglobulin levels are characteristic of multiple myeloma.
Purpose of the Study:
- To investigate coagulation disturbances in multiple myeloma patients.
- To identify the relationship between protein M levels and platelet function.
- To evaluate the effect of treatments on platelet function and protein M levels.
Main Methods:
- Observational study of multiple myeloma patients.
- Assessment of platelet function (adhesion, aggregation).
- Measurement of plasma protein and immunoglobulin levels.
Main Results:
- Platelet dysfunction was observed in patients with marked hyperproteinemia and high immunoglobulin levels.
- Patients without protein disturbances showed normal platelet adhesion and aggregation.
- Chemotherapy and plasma exchange reduced paraprotein levels and normalized platelet function.
Conclusions:
- Paraprotein M in plasma is implicated in the coagulation disturbances seen in multiple myeloma.
- Reducing M protein levels can reverse platelet dysfunction.
- This highlights the importance of managing hyperproteinemia in multiple myeloma patients.