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Updated: May 3, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
[Survival analysis for different molecular subtypes of breast cancers after treatment]
Ying-jian He1, Jin-feng Li1, Tian-feng Wang1
1Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Objective:
To explore the survival status after treatment for patients with different molecular subtypes of breast cancers.
Methods:
A total of 4491 patients with invasive breast cancer from January 2000 to July 2011 were retrospectively recruited to receive pathological verification and treatment at our clinic. According to the immunohistochemical results of hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2), they were assigned into 3 groups of HR+/HER2-, HER2+ and HR-/ HER2-. Survival analyses were conducted to examine the effects of molecular subtypes and lymph node status on survival.
Results:
The 3-year recurrence free survival for HR+/HER2-, HER2+ and HR-/HER2- were 94.9%, 89.5% ane 92.3% respectively. Different molecular subtypes presented different survival patterns (P = 0.0001). The 3-year recurrence-free survival (RFS) for LN+ and LN- was 87.1% and 97.8% respectively. And statistical difference existed (P < 0.01). No difference was detected among three molecular subtypes of LN- (P = 0.102); However, for LN+ patients, HR+/HER2- showed a higher RFS than HER2+ and HR-/HER2 (P = 0.001).
Conclusion:
Different molecular subtypes of breast cancers have varying survival. And lymph node status is probably an important prognostic factor.
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