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Updated: May 3, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
Role of chemokines in proteinuric kidney disorders
Juan Antonio Moreno1, Sara Moreno2, Alfonso Rubio-Navarro1
1Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
Abstract:
Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent progress in cellular and molecular understanding of the role of chemokines in the pathogenesis of proteinuria-induced renal injury, as well as their clinical implications and therapeutic potential.
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