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Updated: Oct 13, 2026

Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
[Changes in the nuclei of the mammary glandular cells in the secretory cycle]
Abstract:
At the early stages of the secretory cycle, the activation of secretory cell nuclear chromatin is observed: the binding of acridine orange increases, while chromatin condensation in the peripheral zone of the nucleus decreases. The increase of the chromatin transcriptional activity provides for a significant increase in cytoplasmic RNA. Under the action of oxytocin reaction product granules are accumulated in conglomerates suggesting some changes in calcium distribution in the decondensed chromatin.
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