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Androgen concentration in blacks with benign and malignant prostatic disease
1College of Medicine, University of Lagos, Nigeria.
The Journal of Urology
|July 1, 1988
Summary
Serum and prostate androgen levels in Nigerians with benign prostatic hyperplasia (BPH) and prostate cancer were similar to Caucasian populations. Differences in prostate cancer incidence may not be linked to androgen levels.
Area of Science:
- Endocrinology
- Urology
- Oncology
Background:
- Prostate cancer and benign prostatic hyperplasia (BPH) incidence varies globally.
- Androgens, particularly testosterone, are implicated in prostate health and disease.
- Nigerians represent a low-risk population for prostatic tumors, making them a unique study group.
Purpose of the Study:
- To measure serum and prostate gland concentrations of testosterone and its metabolites in Nigerian men.
- To compare androgen levels in normal, BPH, and prostate cancer patients.
- To investigate the potential role of androgens in explaining ethnic variations in prostate disease incidence.
Main Methods:
- Radioimmunoassay was used to measure testosterone and metabolite concentrations.
- Serum and prostate tissue samples were analyzed after solvent and chromatographic extraction.
- Statistical analysis was performed to compare hormone levels between different patient groups.
Main Results:
- Serum testosterone levels were similar in normal and BPH patients but significantly lower in prostate cancer patients.
- Testosterone metabolite concentrations were consistent across all groups, but ratios differed in cancer patients.
- Prostate tissue testosterone concentrations were higher in malignant glands than in hypertrophic glands.
- DHT concentrations were higher in BPH glands compared to cancerous glands.
Conclusions:
- Androgen concentrations and distribution patterns in Nigerian men are comparable to Caucasian and Black American populations.
- Observed differences in prostate cancer incidence among ethnic groups may not be solely attributable to androgen levels.
- Further research is needed to elucidate the multifactorial etiology of prostate diseases.
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