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Systematic genome sequence differences among leaf cells within individual trees.

Deepti Diwan, Shun Komazaki, Miho Suzuki

¹Graduate School of Science and Engineering, Department of Functional Materials Science, Saitama University, Saitama 338-8570, Japan. koichi@fms.saitama-u.ac.jp.

|February 20, 2014

Summary

This summary is machine-generated.

Cells within a single plant show distinct genomes, with variations correlating to physical distance. This genomic divergence, measured by genome profiling (GP), suggests accumulated mutations from cell division impact genome stability.

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Area of Science:

Genomics
Plant Biology
Cellular Biology

Background:

The question of whether individual cells within an organism possess systematically distinct genomes remains unresolved, even with advanced next-generation sequencing (NGS).
Understanding genome variation within an organism is crucial for elucidating fundamental biological processes, including DNA mutation rates and cancer mechanisms.

Purpose of the Study:

To investigate the extent of systematic genomic variation among cells within individual woody plants.
To determine if genomic differences correlate with physical location within the plant.

Main Methods:

Genome profiling (GP) was employed to analyze and compare genome sequences of cells from different parts of individual plants.
Genomic distance was calculated to quantify sequence variation between cells.

Main Results:

Significant systematic variation in genome sequences was detected among cells within individual woody plants (Yoshino cherry and Japanese beech).
Genomic distance exhibited a systematic pattern, increasing from the bottom to the top of the plant, with the highest divergence between uppermost leaf genomes and other tree parts.
This variation was consistently observed across different plant species examined.

Conclusions:

The genomic distance between cells within an individual organism is substantial and not negligible, as indicated by GP measurements.
Genomic divergence was found to be correlated with the physical distance between cells, specifically branch-to-branch distance.
This phenomenon is hypothesized to result from the accumulation of mutations during cell division, with divergence proportional to the number of cell generations.