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The Angiomotins--from discovery to function

Susana Moleirinho1, William Guerrant1, Joseph L Kissil1

  • 1Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

FEBS Letters
|February 20, 2014
PubMed

Insights

Motin proteins, initially known for regulating endothelial cells, are now recognized for their role in epithelial cells and cancer pathogenesis. This review explores their function in key signaling pathways, including small G-proteins and the Hippo-YAP pathway.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Angiomotins, identified as angiostatin binding proteins, regulate endothelial cell migration.
  • Emerging research highlights the Motin protein family's involvement in epithelial cells and cancer development.
  • Motins are implicated in signaling pathways crucial for cellular processes.

Purpose of the Study:

  • To review the role of the Motin protein family in cancer pathogenesis.
  • To describe the involvement of Motins in small G-protein and Hippo-YAP signaling pathways.
  • To discuss current knowledge gaps and future research directions regarding Motins.

Main Methods:

  • Literature review of studies on Angiomotins and Motin proteins.
  • Analysis of research linking Motins to epithelial cell function and cancer.
  • Examination of Motin interactions within small G-protein and Hippo-YAP signaling cascades.

Main Results:

  • Motins play a significant role in epithelial cell biology.
  • The Motin protein family is increasingly linked to the pathogenesis of various cancers.
  • Motins are key regulators in pathways involving small G-proteins and the Hippo-YAP signaling network.

Conclusions:

  • The Motin protein family is a critical player in both normal cellular functions and cancer.
  • Understanding Motin signaling pathways offers potential therapeutic targets for cancer treatment.
  • Further research is needed to fully elucidate the complex roles of Motins in disease.
Keywords:
AngiomotinAngiomotin-like 1Angiomotin-like 2HippoMerlinMotinNF2YAP

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