Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.4K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

4.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
4.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

6.4K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
6.4K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

8.6K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.6K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.8K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat.

Cancer discovery·2025
Same author

NF2-associated schwannomatosis (NF2): genetics, manifestations, and emerging therapeutic approaches.

Trends in molecular medicine·2025
Same author

The L27 domain of MPP7 enhances TAZ-YY1 cooperation to renew muscle stem cells.

EMBO reports·2024
Same author

Synergistic effects of combined BET and FAK inhibition against Vestibular Schwannomas in NF2-related Schwannomatosis.

Oncogene·2024
Same author

The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells.

Research square·2023
Same author

The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells.

bioRxiv : the preprint server for biology·2023

Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.7K

The Angiomotins--from discovery to function.

Susana Moleirinho1, William Guerrant1, Joseph L Kissil1

  • 1Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

FEBS Letters
|February 20, 2014
PubMed
Summary

Motin proteins, initially known for regulating endothelial cells, are now recognized for their role in epithelial cells and cancer pathogenesis. This review explores their function in key signaling pathways, including small G-proteins and the Hippo-YAP pathway.

Keywords:
AngiomotinAngiomotin-like 1Angiomotin-like 2HippoMerlinMotinNF2YAP

More Related Videos

Rat Mesentery Angiogenesis Assay
18:30

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

13.9K
Visualization and Quantitative Analysis of Embryonic Angiogenesis in Xenopus tropicalis
06:05

Visualization and Quantitative Analysis of Embryonic Angiogenesis in Xenopus tropicalis

Published on: May 25, 2017

7.9K

Related Experiment Videos

Last Updated: May 2, 2026

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.7K
Rat Mesentery Angiogenesis Assay
18:30

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

13.9K
Visualization and Quantitative Analysis of Embryonic Angiogenesis in Xenopus tropicalis
06:05

Visualization and Quantitative Analysis of Embryonic Angiogenesis in Xenopus tropicalis

Published on: May 25, 2017

7.9K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Angiomotins, identified as angiostatin binding proteins, regulate endothelial cell migration.
  • Emerging research highlights the Motin protein family's involvement in epithelial cells and cancer development.
  • Motins are implicated in signaling pathways crucial for cellular processes.

Purpose of the Study:

  • To review the role of the Motin protein family in cancer pathogenesis.
  • To describe the involvement of Motins in small G-protein and Hippo-YAP signaling pathways.
  • To discuss current knowledge gaps and future research directions regarding Motins.

Main Methods:

  • Literature review of studies on Angiomotins and Motin proteins.
  • Analysis of research linking Motins to epithelial cell function and cancer.
  • Examination of Motin interactions within small G-protein and Hippo-YAP signaling cascades.

Main Results:

  • Motins play a significant role in epithelial cell biology.
  • The Motin protein family is increasingly linked to the pathogenesis of various cancers.
  • Motins are key regulators in pathways involving small G-proteins and the Hippo-YAP signaling network.

Conclusions:

  • The Motin protein family is a critical player in both normal cellular functions and cancer.
  • Understanding Motin signaling pathways offers potential therapeutic targets for cancer treatment.
  • Further research is needed to fully elucidate the complex roles of Motins in disease.