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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Updated: May 2, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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Regulatory non-coding RNAs: revolutionizing the RNA world.

Biao Huang1, Rongxin Zhang

  • 1Research Center of Basic Medical Science; Department of Immunology, Basic Medical College; Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironments and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, 300070, China.

Molecular Biology Reports
|February 20, 2014
PubMed
Summary
This summary is machine-generated.

Regulatory non-coding RNAs (ncRNAs), including small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), play crucial roles in cellular regulation. This review details their diverse mechanisms of action in intracellular events.

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Area of Science:

  • Genomics
  • Molecular Biology
  • RNA Biology

Background:

  • Mammalian genomes contain abundant functional RNA transcripts.
  • Regulatory non-coding RNAs (ncRNAs) are key in development and species-specific regulation.

Purpose of the Study:

  • To review regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs).
  • To summarize the distinct modes of action for sncRNAs and lncRNAs.

Main Methods:

  • Literature review of regulatory ncRNAs.
  • Categorization of sncRNA and lncRNA functions.

Main Results:

  • Identified two distinct modes of action for sncRNAs.
  • Detailed eight distinct modes of action for lncRNAs.

Conclusions:

  • Functional ncRNAs regulate intracellular events through diverse mechanisms.
  • Understanding these mechanisms is vital for comprehending cellular processes.