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Related Experiment Videos

Nitrendipine/digoxin interaction.

W Kirch1, C Logemann, H Heidemann

  • 1I. Medizinische Klinik, Christian Albrechts University of Kiel, F.R.G.

Journal of Cardiovascular Pharmacology
|January 1, 1987
PubMed
Summary
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Nitrendipine, a calcium channel blocker, significantly increases digoxin plasma levels and AUC when taken at 20 mg daily. This interaction may be clinically relevant for patients on digoxin therapy.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy

Background:

  • Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
  • Nitrendipine is a dihydropyridine calcium channel blocker.
  • Potential drug interactions between digoxin and calcium channel blockers require investigation.

Purpose of the Study:

  • To evaluate the effect of nitrendipine on digoxin pharmacokinetics.
  • To assess the impact of two different nitrendipine dosages on digoxin plasma levels and urinary recovery.
  • To determine the clinical relevance of nitrendipine-digoxin interactions.

Main Methods:

  • Eight healthy volunteers participated in the study.
  • Digoxin (0.25 mg twice daily) was administered alone and combined with nitrendipine (10 mg or 20 mg once daily).

Related Experiment Videos

  • Plasma concentrations, urinary recovery, and systolic time intervals were measured.

    • Main Results:

    • Nitrendipine 20 mg/day significantly increased digoxin plasma concentration and area under the curve (AUC0-12) compared to digoxin monotherapy (11.2 +/- 0.92 ng ml-1 h vs. 9.7 +/- 0.75 ng ml-1 h, p < 0.05).
    • Nitrendipine 10 mg/day showed a minor, non-significant increase in digoxin levels.
    • No significant changes in urinary recovery or systolic time intervals were reported.

    Conclusions:

    • Nitrendipine, at a dosage of 20 mg daily, significantly elevates digoxin plasma concentrations and AUC.
    • This interaction may have clinical implications for patients requiring concurrent digoxin and nitrendipine therapy.
    • Further studies are warranted to fully elucidate the clinical significance of this interaction.