Related Experiment Video

Updated: May 2, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

555

Cellular Response to Ionizing Radiation: A MicroRNA Story

Mohammad Halimi1, S Mohsen Asghari1, Reyhaneh Sariri1

  • 1Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.

International Journal of Molecular and Cellular Medicine
|February 20, 2014
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are involved in cellular responses to ionizing radiation (IR). Understanding miRNA roles in radiation response can improve cancer radiotherapy. Keywords: microRNAs, gene regulation, ionizing radiation, cancer treatment, radiotherapy.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • They are vital in numerous cellular processes.
  • Ionizing radiation (IR) is a key cancer treatment impacting cellular functions.

Purpose of the Study:

  • To review recent findings on microRNAs in cellular responses to ionizing radiation.
  • To explore the role of miRNA-mediated gene regulation in radiation-related pathways.
  • To highlight the potential of understanding miRNAs for enhancing radiotherapy.

Main Methods:

  • Literature review of recent discoveries.
  • Analysis of miRNA involvement in cellular response to IR.
  • Synthesis of current knowledge on miRNA-radiation interactions.

Main Results:

  • MicroRNA-mediated gene regulation significantly interferes with cellular responses to ionizing radiation.
  • miRNAs are implicated in various radio-related pathways.
  • Emerging evidence links specific miRNAs to radiosensitivity and radioresistance.

Conclusions:

  • Understanding miRNA mechanisms in radiation response is crucial.
  • Targeting miRNAs could offer novel strategies to improve radiotherapy efficacy.
  • Further research into miRNAs may lead to better cancer treatment outcomes.
Keywords:
Cellular responseionizing radiationmicroRNA

More Related Videos

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.5K
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

7.6K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.1K
MicroRNAs01:22

MicroRNAs

9.8K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.5K
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.4K