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Cord blood banking and transplantation: advances and controversies

Mervin C Yoder1

  • 1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Current Opinion in Pediatrics
|February 21, 2014
PubMed

Insights

Cord blood banking and stem cell transplantation have advanced significantly, benefiting over 30,000 patients. Future research into expanding cord blood stem cells may increase demand for this vital therapy.

Area of Science:

  • Hematology
  • Regenerative Medicine
  • Transplant Immunology

Background:

  • Umbilical cord blood (UCB) stem cell transplantation is a recognized alternative for hematopoietic stem cell transplants.
  • UCB is particularly valuable for patients from racial and ethnic minority groups.
  • The first human cord blood transplant occurred 25 years ago, marking a significant milestone.

Purpose of the Study:

  • To review advancements in cord blood banking and stem cell transplantation since January 2012.
  • To assess the current state and future potential of UCB therapies.

Main Methods:

  • Systematic review of articles published since January 2012.
  • Analysis of trends in cord blood banking and transplantation practices worldwide.

Main Results:

  • Cord blood banking is globally established.
  • UCB transplantation is a viable option for pediatric and adult patients.
  • Enhancement methods for UCB stem cell expansion, engraftment, and maintenance are needed.
  • Debate continues regarding optimal and sustainable cord blood banking models.

Conclusions:

  • Cord blood banking and transplantation have seen rapid progress in 25 years, with over 30,000 patients treated.
  • Emerging techniques for expanding UCB stem cells for transplantation and non-hematopoietic uses are expected to drive future demand.
Abstract

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