New humulenes from Hyptis incana (Labiatae)
Mitsuru Satoh1, Yoshio Satoh2, Yasuhiro Anzai3
1Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543 Japan. ms@ac.shoyaku.ac.jp
Abstract:
Two new humulene-type sesquiterpenes, named hyptishumulene I (1) and II (2), have been isolated, together with eight known compounds, a humulene-type sesquiterpene (3), a monoterpene (4) and six abietane-type diterpenoids (5-10) from the aerial parts of Hyptis incana (Labiatae). The cytotoxic activity of the isolated compounds against mouse leukemia cells (L1210) was examined. The abietane-type diterpenoids (5-10) showed rather potent growth inhibitory activity (IC50<15 microM), while the new humulene-type compounds (1 and 2) exhibited moderate activity (IC50>50 microM).
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