A new cyclopeptide from endophytic Streptomyces sp. YIM 64018
Xueqiong Yang1, Yabin Yang1, Tianfeng Peng1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry ofEducation, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
Abstract:
One new cyclopeptide, cyclo(L-Phe-L-Ala-L-Phe-Gly), named as vinaceuline (1) and three known cyclodipeptides, cyclo (Phe-Gly), cyclo (Phe-4-hydroxyl-Pro) and cyclo (Phe-Ile) were isolated from broth culture of endophytic Streptomyces YIM 64018 associated with Paraboea sinensis. The planar structure of the new compound was assigned on the basis of 1D and 2D NMR spectroscopic techniques, while t he a bsolute configurations of the amino acid residueswere determined by application of the advanced Marfey method. Cyclotetrapeptides are rarely found as Streptomycete metabolites.
