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Updated: May 2, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Interferon-stimulated genes: a complex web of host defenses
William M Schneider1, Meike Dittmann Chevillotte, Charles M Rice
1Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065; email: wschneider@rockefeller.edu , mchevillot@rockefeller.edu , ricec@rockefeller.edu.
Abstract:
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production. Next, we describe ways in which ISGs both enhance innate pathogen-sensing capabilities and negatively regulate signaling through the JAK-STAT pathway. Several ISGs that directly inhibit virus infection are described with an emphasis on those that impact early and late stages of the virus life cycle. Finally, we describe ongoing efforts to identify and characterize antiviral ISGs, and we provide a forward-looking perspective on the ISG landscape.
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