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Related Experiment Videos

Cluster headache: lack of central modulation?

A Boiardi1, F Frediani, M Leone

  • 1Headache Centre, Neurologic Institute C Besta, Milan, Italy.

Functional Neurology
|January 1, 1988
PubMed
Summary
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Cluster headache (CH) attacks may involve central nervous system asymmetries. Brainstem Auditory Evoked Potentials (BAEPs) and Visual Evoked Potentials (VEPs) revealed significant differences in CH patients, suggesting a potential neurotransmitter disorder.

Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Neurophysiology

Background:

  • Cluster headache (CH) is a debilitating neurological disorder characterized by severe unilateral pain and autonomic symptoms.
  • The SPergic pathway is implicated in the initiation of CH attacks, but underlying central functional asymmetries remain unclear.

Purpose of the Study:

  • To investigate potential asymmetries in central nervous system functions during cluster headache attacks.
  • To evaluate the utility of Brainstem Auditory Evoked Potentials (BAEPs) and Visual Evoked Potentials (VEPs) in detecting these asymmetries.

Main Methods:

  • A comparative study involving 14 cluster headache patients (7 right-sided, 7 left-sided) and 14 healthy controls.
  • Assessment of Brainstem Auditory Evoked Potentials (BAEPs) and Visual Evoked Potentials (VEPs) in all participants.

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Main Results:

  • All cluster headache patients exhibited significant Visual Evoked Potential (VEP) asymmetry.
  • A reduced mean P100 amplitude was observed on the pain-involved side in VEPs.
  • Increased I-V latency of Brainstem Auditory Evoked Potentials (BAEPs) was noted on the symptomatic side.

Conclusions:

  • The findings suggest underlying central functional asymmetries in cluster headache patients.
  • These asymmetries, detected via VEP and BAEP, may indicate a hemispheric manifestation of a neurotransmitter disorder.