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Updated: May 2, 2026
A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers
Tom L G M van den Kerkhof1, Zelda Euler, Marit J van Gils
1aDepartment of Experimental Immunology and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam bCrucell Holland BV, Leiden cDepartment of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands dDepartment of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York eRagon Institute of MGH, MIT and Harvard, Charlestown, Massachusetts, USA.
Abstract:
Broadly reactive neutralizing activity (brNA) against HIV-1 is observed in 10-30% of infected individuals and generally takes 2-4 years to develop. Here, we show that two elite neutralizers, infected through injecting drug use, developed brNA around the first year postseroconversion (post-SC), whereas criteria for elite brNA were fulfilled around 30 months post-SC. These results indicate that brNA does not necessarily require multiple years to develop and they should encourage the search for vaccines that can elicit protective humoral immunity.
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