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Sensitivities of bleomycin-resistant variant cells enhanced by 40 degrees C hyperthermia in vitro
E Kano1, M Furukawa-Furuya, K Nitta
1Department of Experimental Radiology and Health physics, Fukui Medical University, Japan.
Abstract:
Cultured mammalian cells of higher (mouse L) and lower (Chinese hamster V-79) sensitivities to bleomycin (BLM) were repeatedly treated with BLM (0.1 mg/ml), through which BLM-resistant variant strains were induced. Sensitivities of these variant strains to BLM were enhanced by simultaneous treatment with 40 degrees C hyperthermia.