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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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[Aspirin: once or twice a day?]
Pierre Fontana1, Alessandro Casini2, Françoise Boehlen3
1Service d'angiologie et d'hémostase, HUG, 1211 Genève 14. pierre.fontana@hcuge.ch
Revue Medicale Suisse
|February 25, 2014
Summary
Daily aspirin dosing may be less effective for patients with increased platelet turnover, like those with diabetes. Twice-daily dosing might offer more consistent platelet inhibition in these individuals, supporting personalized antiplatelet therapy.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Hematology
Context:
- Aspirin is a standard for preventing ischemic events, typically prescribed once daily.
- This regimen is based on a daily platelet renewal rate of 10-15%.
Purpose:
- To review aspirin dosing strategies in specific patient populations.
- To address the controversy surrounding personalized antiplatelet therapy.
Summary:
- Once-daily aspirin may provide insufficient platelet inhibition when platelet turnover is elevated (e.g., in diabetes, essential thrombocytemia).
- Studies suggest increased platelet function recovery between doses with standard regimens.
- Twice-daily aspirin dosing may achieve more homogeneous platelet inhibition in these patients.
Impact:
- Challenges conventional once-daily aspirin dosing recommendations.
- Highlights the need for personalized antiplatelet strategies.
- Informs clinical practice for patients requiring enhanced ischemic event prevention.
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