Related Experiment Video
Updated: May 2, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
[Classification of cardiomyopathy]
Masanori Asakura1, Masafumi Kitakaze1
1National Cerebral and Cardiovascular Center, Department of Clinical Medicine and Development, Clinical Research Planning Office, Suita 565-8565.
Insights
Cardiomyopathy, a serious heart muscle disease, has varied forms and causes. Current classifications, though evolving, are crucial for understanding and managing these complex cardiovascular conditions.
Area of Science:
- Cardiology
- Genetics
- Pathophysiology
Context:
- Cardiomyopathy encompasses diverse heart muscle diseases with significant morbidity and mortality.
- Dilated cardiomyopathy may necessitate heart transplantation due to heart failure.
- Hypertrophic cardiomyopathy poses risks of sudden cardiac death from arrhythmias.
Purpose:
- To highlight the importance of classifying cardiomyopathies.
- To address the challenges in establishing a definitive classification due to unclear etiologies.
- To review the evolution of cardiomyopathy definitions and classifications.
Summary:
- Cardiomyopathies are heterogeneous cardiovascular diseases with poor prognoses.
- Existing classifications, like the 1995 WHO/ISFC task force guidelines, are often used.
- Recent updates from major cardiovascular societies (AHA, ESC, JCS) reflect ongoing efforts to refine classification.
Impact:
- Improved understanding of cardiomyopathy phenotypes.
- Facilitation of more accurate clinical diagnosis and patient management.
- Foundation for future research into cardiomyopathy causes and treatments.
Abstract:
Cardiomyopathy is a group of cardiovascular diseases with poor prognosis. Some patients with dilated cardiomyopathy need heart transplantations due to severe heart failure. Some patients with hypertrophic cardiomyopathy die unexpectedly due to malignant ventricular arrhythmias. Various phenotypes of cardiomyopathies are due to the heterogeneous group of diseases. The classification of cardiomyopathies is important and indispensable in the clinical situation. However, their classification has not been established, because the causes of cardiomyopathies have not been fully elucidated. We usually use definition and classification offered by WHO/ISFC task force in 1995. Recently, several new definitions and classifications of the cardiomyopathies have been published by American Heart Association, European Society of Cardiology and Japanese Circulation Society.
Related Concept Videos
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy
Cardiomyopathy II: Dilated Cardiomyopathy
Heart Failure IV: Classification and Diagnostic Evaluation
Cardiomyopathy V: Interprofessional Care

