Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

5.3K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
5.3K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

5.6K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
5.6K
Neural Circuits01:25

Neural Circuits

3.0K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.0K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

4.9K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
4.9K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

3.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
3.2K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

12.1K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
12.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.

Nature methods·2026
Same author

Computational optimization of two-photon holographic stimulation sites<i>in vivo</i>.

Journal of neural engineering·2026
Same author

All-optical voltage interrogation for probing synaptic plasticity in vivo.

Nature communications·2025
Same author

Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings.

Neuron·2025
Same author

A real-time all-optical interface for dynamic perturbation of neural activity during behavior.

Cell reports methods·2025
Same author

Brain-wide representations of prior information in mouse decision-making.

Nature·2025

Related Experiment Video

Updated: May 2, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

6.2K

Structured connectivity in cerebellar inhibitory networks.

Sarah Rieubland1, Arnd Roth1, Michael Häusser1

  • 1Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.

Neuron
|February 25, 2014
PubMed
Summary

Researchers discovered specific, nonrandom connectivity patterns in cerebellar interneuron networks. These findings reveal structured organization in both chemical and electrical synapses, crucial for neural circuit function.

More Related Videos

Revealing Neural Circuit Topography in Multi-Color
09:11

Revealing Neural Circuit Topography in Multi-Color

Published on: November 14, 2011

14.5K
Cerebellar Regional Dissection for Molecular Analysis
08:51

Cerebellar Regional Dissection for Molecular Analysis

Published on: December 5, 2020

4.4K

Related Experiment Videos

Last Updated: May 2, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

6.2K
Revealing Neural Circuit Topography in Multi-Color
09:11

Revealing Neural Circuit Topography in Multi-Color

Published on: November 14, 2011

14.5K
Cerebellar Regional Dissection for Molecular Analysis
08:51

Cerebellar Regional Dissection for Molecular Analysis

Published on: December 5, 2020

4.4K

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Computational Neuroscience

Background:

  • Understanding neural circuit function relies on defining synaptic connectivity rules.
  • Interneurons utilize both electrical and chemical synapses, but their combined organization remains unclear.

Purpose of the Study:

  • To investigate the organization and interaction of electrical and chemical synapses in cerebellar interneuron networks.
  • To identify specific connectivity patterns and motifs within these networks.

Main Methods:

  • Multi-site recordings from molecular layer interneurons in the cerebellar cortex.
  • Analysis of GABAergic chemical and electrical synaptic connectivity patterns.

Main Results:

  • Identified specific, nonrandom connectivity patterns in both chemical and electrical interneuron networks.
  • Observed clustered motifs and overlap between the two network types.
  • Chemical connections showed a preference for transitive patterns (e.g., feedforward triplets).
  • Chemical connectivity transitivity was directed vertically in the sagittal plane; electrical synapses were confined to the sagittal plane.

Conclusions:

  • The cerebellar interneuron networks exhibit highly structured connectivity rules.
  • These structured motifs, including transitive chemical connections and spatially organized electrical synapses, are likely essential for cerebellar network function.