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Intestinal macrophages and DCs close the gap on tolerance

Guy Shakhar1, Masha Kolesnikov1

  • 1Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Immunity
|February 25, 2014
PubMed

CD103(+) dendritic cells (DCs) must acquire soluble food antigens from the gut lumen to induce oral tolerance. In this issue of Immunity, Mazzini et al. (2014), report that CX3CR1(+) macrophages capture such antigen and transfer it to the DCs by a route involving gap junctions.

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