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Updated: May 2, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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[Primary renal synovial sarcoma].

S Trolliet1, V Lindner2, S Krzisch3

  • 1Service d'urologie, Nouvel hôpital civil, 1, place de l'Hôpital, 67091 Strasbourg, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|February 25, 2014
PubMed
Summary
This summary is machine-generated.

Primary renal synovial sarcoma is a rare kidney tumor. Molecular diagnosis confirmed a unique t(X;18) translocation with SYT-SSX2 fusion transcripts in a patient with vascular invasion.

Keywords:
Cancer du reinRenal tumorReverse transcription polymerase chain reactionSYT-SSXSarcomaSarcomeSynovial sarcomaSynovialosarcomeTranslocation chromosomique t(X ;18)t(X ;18) chromosomal translocation

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Primary renal synovial sarcoma is an exceptionally rare malignancy.
  • It presents diagnostic challenges due to overlapping features with other mesenchymal renal tumors.
  • Fewer than 60 cases are documented in medical literature.

Observation:

  • A 66-year-old male patient presented with a primary synovial sarcoma of the right kidney.
  • The tumor exhibited vascular invasion into the inferior vena cava and right renal vein.
  • Clinical and histological features mimicked other mesenchymal kidney tumors.

Findings:

  • Molecular analysis using reverse transcription polymerase chain reaction (RT-PCR) confirmed the diagnosis.
  • A unique chromosomal translocation t(X;18) was identified.
  • SYT-SSX2 fusion transcripts were detected, characteristic of synovial sarcoma.

Implications:

  • This case highlights the importance of molecular diagnostics in rare renal tumors.
  • Accurate diagnosis is crucial for appropriate management and prognosis of renal synovial sarcoma.
  • Understanding the genetic underpinnings, such as SYT-SSX2 fusion, aids in classifying and potentially treating this rare cancer.