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Updated: May 2, 2026

ROS Live Cell Imaging During Neuronal Development
Published on: February 9, 2021
Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases
Ralf P Brandes1, Norbert Weissmann2, Katrin Schröder1
1Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt, Germany.
Abstract:
The only known function of the Nox family of NADPH oxidases is the production of reactive oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the ROS locally produced are required for synthesis of hormones or tissue components. In the cardiovascular system, Nox enzymes are low abundant and function as redox-modulators. By reacting with thiols, nitric oxide (NO) or trace metals, Nox-derived ROS elicit a plethora of cellular responses required for physiological growth factor signaling and the induction and adaptation to pathological processes. The interactions of Nox-derived ROS with signaling elements in the cardiovascular system are highly diverse and will be detailed in this article, which is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".
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