Related Experiment Video

Updated: May 2, 2026

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

1.1K

MicroRNAs in pancreatic malignancy: progress and promises

Sanjeev K Srivastava1, Sumit Arora1, Seema Singh1

  • 1Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.

Cancer Letters
|February 25, 2014
PubMed

Insights

MicroRNAs (miRNAs) are key players in pancreatic cancer development and resistance to therapy. This review explores their potential as diagnostic, prognostic, and therapeutic tools for this challenging disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Pancreatic cancer presents a significant clinical challenge with rising incidence and mortality rates.
  • There is a critical need for advanced diagnostic, prognostic, and therapeutic strategies for effective pancreatic cancer management.

Purpose of the Study:

  • To review the current understanding of microRNA (miRNA) roles in pancreatic cancer.
  • To discuss the potential clinical applications of miRNAs as biomarkers and therapeutic targets.

Main Methods:

  • Literature review of recent studies on miRNA deregulation in pancreatic cancer.
  • Analysis of miRNA involvement in cancer initiation, progression, metastasis, and therapeutic resistance.

Main Results:

  • MicroRNAs are frequently deregulated in pancreatic cancer.
  • These microRNAs significantly influence pancreatic cancer initiation, progression, metastasis, and therapeutic resistance.

Conclusions:

  • MicroRNAs hold promise as diagnostic and prognostic biomarkers for pancreatic cancer.
  • Targeting miRNAs offers a potential avenue for developing novel and effective pancreatic cancer therapies.
Keywords:
DiagnosisDrug resistanceMetastasisMicroRNAsPancreatic cancerPrognosis and therapy

More Related Videos

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

555
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.7K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K