Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.2K
9.2K
The Bone Matrix01:18

The Bone Matrix

9.4K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
9.4K
Fractures: Bone Repair01:27

Fractures: Bone Repair

5.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired bone matrix maturation and mineralization are prevalent in adolescent end-stage kidney disease.

JBMR plus·2026
Same author

Vanadium toxicity and chronic kidney disease: implications in a green new world.

Pediatric nephrology (Berlin, Germany)·2025
Same author

Chromatin accessibility and epigenetic deoxyribose nucleic acid (DNA) modifications in chronic kidney disease (CKD) osteoblasts: a study of bone and osteoblasts from pediatric patients with CKD.

JBMR plus·2024
Same author

Recurrent disease after pediatric renal transplantation.

Pediatric transplantation·2024
Same author

Comparison of estimated GFR using cystatin C versus creatinine in pediatric kidney transplant recipients.

Pediatric nephrology (Berlin, Germany)·2024
Same author

Quality of life in pediatric chronic kidney disease: expectations and responsibilities.

Pediatric nephrology (Berlin, Germany)·2023

Related Experiment Video

Updated: May 2, 2026

Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

10.8K

The BRC canopy: an important player in bone remodeling.

Katherine Wesseling-Perry1

  • 1Department of Pediatrics, University of California, Los Angeles, School of Medicine, Los Angeles, California.

The American Journal of Pathology
|February 25, 2014
PubMed
Summary

This commentary discusses bone structural changes linked to increased bone resorption in post-menopausal women with osteoporosis. These findings offer insights into osteoporosis progression and potential therapeutic targets.

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K
Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
09:07

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

6.1K

Related Experiment Videos

Last Updated: May 2, 2026

Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

10.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K
Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
09:07

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

6.1K

Area of Science:

  • Bone biology and skeletal health.

Background:

  • Osteoporosis is a significant skeletal disorder characterized by low bone mass and microarchitectural deterioration.
  • Post-menopausal women are at higher risk for osteoporosis due to hormonal changes affecting bone metabolism.

Purpose of the Study:

  • To highlight and discuss the findings of Andersen et al. regarding bone structural changes.
  • To emphasize the association between increased bone resorption and these structural alterations in osteoporotic post-menopausal women.

Main Methods:

  • The commentary reviews the methodology used by Andersen et al. to assess bone structure.
  • Analysis of bone resorption markers and their correlation with observed structural changes.

Main Results:

  • Structural changes in bone are evident in osteoporotic post-menopausal women.
  • Increased bone resorption is a key factor contributing to these detrimental structural modifications.

Conclusions:

  • The findings underscore the critical role of bone resorption in the pathogenesis of osteoporosis.
  • Understanding these structural changes is vital for developing effective osteoporosis treatments.