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Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a

Binjun Yan1, Teng Chen1, Zhilin Xu1

  • 1Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China.

Journal of Pharmaceutical and Biomedical Analysis
|February 25, 2014
PubMed
Summary

This study introduces a rapid process development method using direct analysis in real time mass spectrometry (DART-MS) as a process analytical technology (PAT) tool. It demonstrates faster chromatographic process analysis for improved quality by design (QbD) implementation in pharmaceuticals.

Keywords:
Chromatographic processDirect analysis in real time mass spectrometryGinkgolidesProcess analytical technologyQuality by design

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