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Related Experiment Video

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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

Birgit Frilling1, R Schiele, R Zahn

  • 1Herzzentrum Ludwigshafen Kardiologie Bremserstr. 79 67069 Ludwigshafen, Germany Tel.: 0621/503-4000 Fax: 0621-503-4002 E-Mail: frillinb@klilu.de, DE.

Zeitschrift Fur Kardiologie
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PubMed
Summary
This summary is machine-generated.

In acute myocardial infarction (AMI) therapy, 92% of patients received heparin. While complications were slightly higher, heparin use was linked to significantly lower mortality rates in clinical practice.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Medicine

Context:

  • Heparin is a common adjunctive therapy for acute myocardial infarction (AMI).
  • Previous randomized trials yielded inconclusive data on heparin's benefits in AMI.
  • Routine clinical practice patterns and outcomes for heparin use in AMI were investigated.

Purpose:

  • To describe the utilization of heparin in acute myocardial infarction (AMI) therapy.
  • To analyze complication rates associated with heparin use in routine clinical practice.
  • To evaluate the impact of heparin on mortality in AMI patients.

Summary:

  • 92% of 22,697 AMI patients in the MITRA and MIR registries (1994-1998) received heparin.
  • Heparin was withheld in patients with bleeding or cardiogenic shock.
  • Heparin use showed only slightly increased complication rates (stroke, bleeding) but significantly lower mortality (14.1% vs. 27.3%).

Impact:

  • Findings suggest heparin is widely used in AMI, with careful patient selection.
  • The study highlights the potential survival benefit of heparin in AMI, despite inconclusive trial data.
  • Results provide insights into real-world heparin use and outcomes in acute myocardial infarction.