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PAF-induced histamine release in the isolated perfused rat kidney
M G Alessandrì1, L Giovannini, M Mian
1Institute of Pharmacology, Medical School, University of Pisa, Italy.
International Journal of Tissue Reactions
|January 1, 1988
Abstract:
The platelet-activating factor (PAF) has been shown to stimulate the release of prostaglandins, leukotrienes and 5HT from a number of cell types. In this work we studied the effects of bolus injections of PAF on the isolated perfused rat kidney. Results showed histological damage at the proximal-tubule level and a significant histamine release.