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Related Experiment Video

Updated: May 2, 2026

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Nuclear envelope invaginations and cancer.

Ashraf N Malhas1, David J Vaux

  • 1Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK, Ashraf.malhas@path.ox.ac.uk.

Advances in Experimental Medicine and Biology
|February 25, 2014
PubMed
Summary

Nuclear envelope (NE) invaginations are linked to cancer, offering potential diagnostic and prognostic insights. This chapter explores their role in tumorigenesis and cancer cell irregularities.

Area of Science:

  • Cell Biology
  • Cancer Research
  • Molecular Biology

Background:

  • The nuclear envelope (NE) is a dynamic structure crucial for nuclear function.
  • NE irregularities, including invaginations, are observed in cancer cells.
  • These morphological changes may have diagnostic and prognostic implications.

Purpose of the Study:

  • To elucidate the connection between nuclear invaginations and cancer.
  • To explore the potential mechanistic roles of NE invaginations in tumorigenesis.

Main Methods:

  • Review of existing literature on nuclear envelope morphology in cancer.
  • Analysis of the functional and structural significance of NE invaginations.
  • Exploration of potential molecular mechanisms driving NE abnormalities in cancer.

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Main Results:

  • Nuclear envelope invaginations and irregularities are characteristic of cancer cells.
  • These NE alterations are associated with diagnostic and prognostic significance in cancer.
  • NE invaginations may play active roles in cancer development and progression.

Conclusions:

  • Nuclear envelope invaginations are more than structural anomalies; they are implicated in cancer biology.
  • Understanding NE invaginations could lead to novel cancer diagnostics and therapeutics.
  • Further research is needed to fully uncover the mechanistic roles of NE invaginations in tumorigenesis.