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Association of alkaline phosphatase with isolated coronary artery ectasia
Qiao-Juan Huang1, Yuan-Lin Guo, Cheng-Gang Zhu
1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , P. R. China.
Insights
Serum alkaline phosphatase (ALP) activity is higher in patients with isolated coronary artery ectasia (CAE). Increased ALP levels independently predict the presence of CAE, suggesting its potential as a diagnostic marker.
Area of Science:
- Cardiology
- Clinical Biochemistry
Background:
- Alkaline phosphatase (ALP) is a known biomarker for cardiovascular events and mortality.
- The association between ALP and isolated coronary artery ectasia (CAE) has not been previously investigated.
Purpose of the Study:
- To investigate the relationship between serum ALP activity and isolated CAE.
- To determine if ALP can serve as a predictor for isolated CAE.
Main Methods:
- A case-control study comparing 79 patients with isolated CAE and 88 healthy controls.
- Serum ALP activity was measured and compared between groups.
- Multivariate analysis and ROC curve analysis were used to assess predictive value.
Main Results:
- Patients with isolated CAE exhibited significantly higher serum ALP activity than controls (72.41 ± 29.97 vs. 59.27 ± 14.46, p < 0.001).
- Elevated ALP levels were identified as an independent predictor for the presence of isolated CAE (OR = 1.037, p < 0.001).
- A cutoff value of ≥ 66.5 U/L demonstrated 60.8% sensitivity and 75.0% specificity for predicting isolated CAE.
Conclusions:
- Serum ALP activity is significantly associated with the presence of isolated CAE.
- Readily available serum ALP levels may aid in identifying individuals with isolated CAE.
Background:
It has been shown that alkaline phosphatase (ALP) is a reliable marker for cardiovascular events and mortality. However, there is no data available regarding the association of ALP with isolated coronary artery ectasia (CAE). The aim of the present study was to assess the serum ALP activity in isolated CAE.
Methods:
Seventy-nine patients with isolated CAE (59 males; mean age, 52 ± 12 years) and 88 age- and gender-matched normal subjects (73 males; mean age, 52 ± 7 years) were enrolled. Baseline characteristics were recorded in both groups and serum ALP activity were compared between the two groups.
Results:
Patients with angiography-proved isolated CAE had significantly higher serum ALP activity compared with angiographic normal controls (72.41 ± 29.97 vs. 59.27 ± 14.46, p < 0.001). In the multivariate analysis, increased ALP (OR = 1.037, 95% CI 1.017-1.057, p < 0.001) were independent predictors for the presence of isolated CAE. A cut-off of ≥ 66.5 U/L of ALP activity measured on admission had a 60.8% sensitivity and 75.0% specificity in predicting isolated CAE by receiver operating characteristic (ROC) curve analysis.
Conclusion:
Our data firstly demonstrated that serum ALP activity, a readily available clinical laboratory value, was associated with the presence of isolated CAE.
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