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Updated: May 2, 2026
Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
Published on: December 15, 2015
Enhancing the separation performance of the first-generation silica monolith using active flow technology: parallel
Arianne Soliven1, Dominic Foley2, Luisa Pereira2
1Australian Centre for Research on Separation Science (ACROSS), School of Science and Health, University of Western Sydney, Parramatta, NSW, Australia.
Abstract:
Active flow technology (AFT) columns are designed to minimise inefficient flow processes associated with the column wall and radial heterogeneity of the stationary phase bed. This study is the first to investigate AFT on an analytical scale 4.6mm internal diameter first-generation silica monolith. The performance was compared to a conventional first-generation silica monolith and it was observed that the AFT monolith had an increase in efficiency values that ranged from 15 to 111%; the trend demonstrating efficiency gains increasing as the volumetric flow to the detector was decreased, but with no loss in sensitivity.
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