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Electrical inhomogeneity in left ventricular hypertrophy

Changzhao Gao1, Dandan Yang

  • 1Department of Clinical Medicine, School of Clinical Medicine, Jilin University, Changchun, Jilin, People's Republic of China.

Cell Biochemistry and Biophysics
|February 26, 2014
PubMed

Insights

Left ventricular hypertrophy worsens heart electrical instability. QT interval dispersion, a measure of repolarization inhomogeneity, is significantly increased in patients with this condition.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Imaging

Background:

  • Left ventricular hypertrophy (LVH) is associated with electrical instability.
  • Aortic compliance and cardiac electrical activity heterogeneity are linked.
  • Repolarization disturbances are a key concern in LVH.

Purpose of the Study:

  • To review mechanisms of electrical inhomogeneity in LVH.
  • To assess the relationship between aortic compliance and heart electrical activity.
  • To highlight valuable indices for repolarization abnormalities in LVH.

Main Methods:

  • Review of recent studies on LVH and cardiac electrical activity.
  • Analysis of parameters like QT dispersion, QRS-T angle, and isointegral maps.
  • Comparison of repolarization indices between LVH patients and normal individuals.

Main Results:

  • LVH significantly aggravates myocardial repolarization disturbances.
  • QT interval dispersion is a valuable index for repolarization inhomogeneity and heart rate variability.
  • Heart rate-corrected QT dispersion and QT apex dispersion are longer in LVH patients.
  • QRST isointegral maps are effective in assessing electro-cardiac events in LVH.

Conclusions:

  • LVH leads to marked repolarization abnormalities.
  • QT dispersion serves as a key indicator of electrical inhomogeneity in LVH.
  • QRST isointegral mapping is a useful technique for evaluating cardiac electrical events in LVH.

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