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Customising PRESAGE® for diverse applications
T Juang1, J Newton1, M Niebanck1
1Duke University Medical Center, Durham, NC, USA.
Journal of Physics. Conference Series
|February 26, 2014
Summary
PRESAGE® dosimeters, customizable solid radiochromic devices, show adaptable dose sensitivity and stability. Tailored formulations offer potential for diverse clinical applications, including remote and deformable dosimetry.
Area of Science:
- Medical Physics
- Materials Science
- Radiological Dosimetry
Background:
- PRESAGE® is a solid radiochromic dosimeter composed of a polyurethane matrix, triarylmethane leuco dye, and trihalomethane initiator.
- Dosimeter properties like sensitivity, stability, and physical characteristics can be modified by altering constituent composition and amounts.
- Customization enables PRESAGE® to meet specific application needs, including high-dose measurements, remote monitoring, reusability, and tissue-mimicking elasticity.
Purpose of the Study:
- To evaluate and characterize five hard, non-deformable PRESAGE® formulations and six deformable PRESAGE® formulations.
- To assess the dose sensitivity and post-irradiation stability of these different PRESAGE® formulations.
- To explore the potential of deformable PRESAGE® formulations for reusability and tissue-like elasticity.
Main Methods:
- Characterization of five hard and six deformable PRESAGE® formulations.
- Measurement of dose sensitivity for all formulations.
- Assessment of post-irradiation stability and optical clearing properties.
- Tensile compression testing of deformable formulations to evaluate elastic response.
Main Results:
- Dose sensitivities ranged from 0.0029 - 0.0467 ΔOD/(Gy·cm) for hard formulations and 0.0003 - 0.0056 ΔOD/(Gy·cm) for deformable formulations.
- Non-deformable formulations exhibited exceptional stability, suitable for remote dosimetry.
- Deformable formulations showed potential for reusability due to strong post-irradiation optical clearing and exhibited elastic properties similar to soft tissues.
Conclusions:
- PRESAGE® dosimeters can be customized for a broad range of clinical applications.
- The evaluated formulations demonstrate flexibility in dose sensitivity and stability.
- Both hard and deformable PRESAGE® formulations show promise for specific dosimetry needs in clinical settings.
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