Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ultrasonography01:17

Ultrasonography

6.5K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
6.5K
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

909
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
909
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

964
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
964

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulsed ultrasound targeted to the spleen mitigates against kidney injury and promotes kidney repair.

American journal of physiology. Renal physiology·2025
Same author

Single Treatment Boiling Histotripsy Focused Ultrasound Ablation Neither Negates nor Enhances the Activity of α-CD40 in a Pancreatic Cancer Model.

IEEE transactions on bio-medical engineering·2025
Same author

Contrast-Enhanced Ultrasound of Mouse Models of Hindlimb Ischemia Reveals Persistent Perfusion Deficits and Distinctive Muscle Perfusion Patterns.

Ultrasound in medicine & biology·2024
Same author

SELFNet: Denoising Shear Wave Elastography Using Spatial-temporal Fourier Feature Networks.

Ultrasound in medicine & biology·2024
Same author

Sonothrombolysis Using Microfluidically Produced Microbubbles in a Murine Model of Deep Vein Thrombosis.

Annals of biomedical engineering·2024
Same author

Focused Ultrasound: Noninvasive Image-Guided Therapy.

Investigative radiology·2024
Same journal

Theoretical Foundations of the Echo Envelope Statistical Modeling: A Tutorial.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Practical Demonstrations of FR3-Band Thin-Film Lithium Niobate Acoustic Filter Design.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Real-Time Heterogeneous Helical Wave Spectrum Method for Transabdominal Passive Acoustic Mapping.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Cascaded Plane Wave Ultrasound Velocity Vector Imaging: In Vivo Feasibility in Carotid Arteries.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Quantitative Acoustic Attenuation Scanning Using a Phase-Insensitive Ultrasound Computed Tomography System.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

FPGA-Accelerated CNN Reconstruction for Low-Power Sparse-Array Ultrasound Imaging.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
See all related articles

Related Experiment Video

Updated: May 2, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique
08:24

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

15.0K

An IVUS transducer for microbubble therapies.

Joseph P Kilroy, Abhay V Patil, Joshua J Rychak

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |February 27, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Modified intravascular ultrasound (IVUS) catheters can deliver drugs locally using microbubbles. Optimized pulse repetition frequency (PRF) is key for effective microbubble displacement and targeted vessel wall delivery.

    More Related Videos

    Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
    06:29

    Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

    Published on: February 5, 2022

    7.2K
    Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
    06:45

    Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

    Published on: June 2, 2023

    2.5K

    Related Experiment Videos

    Last Updated: May 2, 2026

    Introduction to the Ultrasound Targeted Microbubble Destruction Technique
    08:24

    Introduction to the Ultrasound Targeted Microbubble Destruction Technique

    Published on: June 12, 2011

    15.0K
    Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
    06:29

    Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

    Published on: February 5, 2022

    7.2K
    Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
    06:45

    Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

    Published on: June 2, 2023

    2.5K

    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Research
    • Drug Delivery Systems

    Background:

    • Intravascular ultrasound (IVUS) is a diagnostic tool.
    • There is growing interest in combining IVUS with microbubbles for targeted drug delivery.
    • Developing dual-function IVUS catheters for diagnosis and therapy is a key research area.

    Purpose of the Study:

    • To design, prototype, and validate an IVUS transducer for microbubble-based drug delivery.
    • To investigate the acoustic radiation force for microbubble displacement.
    • To assess the feasibility of localized drug delivery to the vessel wall.

    Main Methods:

    • A 1.5-MHz IVUS transducer was designed using acoustic radiation force modeling and finite element analysis.
    • Biotinylated microbubbles were displaced towards a streptavidin-coated wall in a flow phantom using the IVUS transducer.
    • Microbubble adhesion was monitored, and a time constant (τ) was extracted from RF data, with varying pulse repetition frequency (PRF).
    • Ex vivo swine artery experiments were conducted to evaluate fluorophore delivery.

    Main Results:

    • Increasing PRF in water decreased the microbubble displacement time constant (τ).
    • In bovine whole blood, a transition to adhesion occurred at PRFs ≥ 8 kHz.
    • Localized delivery of a fluorophore to a swine artery resulted in a 6.6-fold increase in fluorescence.

    Conclusions:

    • Pulse repetition frequency (PRF) significantly influences IVUS-guided acoustic radiation force microbubble displacement.
    • IVUS combined with microbubbles shows potential for localized drug delivery to the vessel wall.
    • This technology offers a promising approach for dual diagnostic and therapeutic applications in cardiovascular medicine.