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Related Concept Videos

Ultrasonography01:17

Ultrasonography

4.4K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
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Ultrasound I: Abdominal Ultrasonography01:20

Ultrasound I: Abdominal Ultrasonography

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Introduction:
Abdominal ultrasonography, commonly known as abdominal ultrasound, is a vital, non-invasive medical imaging technique widely used in healthcare.
Procedure:
This diagnostic tool allows the clinician to visually inspect internal structures within the abdomen, including vital organs such as the liver, gallbladder, pancreas, kidneys, and spleen.
The abdominal ultrasound process begins with applying a special gel to the patient's skin over the abdomen. This gel enhances the...
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Related Experiment Video

Updated: Jun 16, 2025

Real-time Monitoring of High Intensity Focused Ultrasound HIFU Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound HMIFU
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Real-time Monitoring of High Intensity Focused Ultrasound HIFU Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound HMIFU

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Focused Ultrasound: Noninvasive Image-Guided Therapy.

Chrit T W Moonen1, Joseph P Kilroy, Alexander L Klibanov

  • 1From the Focused Ultrasound Foundation, Charlottesville, VA (C.T.W.M., J.P.K.); and Cardiovascular Division (Department of Medicine) and Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA (A.L.K.).

Investigative Radiology
|August 20, 2024
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Summary
This summary is machine-generated.

Focused ultrasound therapy offers a noninvasive approach to treat diseases, utilizing advanced imaging for precise targeting and monitoring. This method enhances safety and recovery by avoiding surgery and enabling targeted drug delivery, even across the blood-brain barrier.

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Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
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Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

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Area of Science:

  • Interventional Radiology
  • Medical Imaging
  • Acoustic Medicine

Background:

  • Traditional surgery for tumor removal is invasive, carrying risks and extended recovery times.
  • Minimally invasive techniques like laparoscopy and catheter-based procedures have improved patient outcomes.
  • Completely noninvasive methods offer further advantages in reducing risks, procedure duration, and recovery periods.

Purpose of the Study:

  • To review imaging capabilities and approaches for image-guided focused ultrasound interventions.
  • To highlight the integration of imaging in planning, real-time monitoring, and efficacy evaluation of focused ultrasound treatments.
  • To discuss the role of sonosensitive nanoparticles in enhancing focused ultrasound therapies.

Main Methods:

  • Emphasis on magnetic resonance imaging (MRI) and ultrasound for guidance and monitoring.
  • Integration of imaging for treatment planning, defining target regions, and identifying organs at risk.
  • Real-time monitoring using thermometry, cavitation feedback, and motion control for safety and accuracy.
  • Evaluation of treatment efficacy through ablation assessment and physiological parameter monitoring (e.g., blood supply).

Main Results:

  • Focused ultrasound enables noninvasive localized hyperthermia, mechanical ablation, and targeted drug delivery.
  • Advanced imaging, particularly MRI and ultrasound, is crucial for planning, guiding, and monitoring focused ultrasound procedures.
  • Sonosensitive microparticles and nanoparticles enhance ultrasound energy deposition, enabling microvascular interventions and targeted drug/gene delivery.
  • Noninvasive opening of the blood-brain barrier for targeted drug delivery in the brain is a significant advancement.

Conclusions:

  • Image-guided focused ultrasound is a rapidly evolving, noninvasive tool for disease treatment.
  • It offers significant advantages over traditional and minimally invasive surgical approaches.
  • Further development promises broader clinical applications in interventional radiology.