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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
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Updated: May 2, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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[Overwhelming postsplenectomy infection syndrome].

C Fuchs1, C Scheer, K Schulz

  • 1Klinik und Poliklinik für Anästhesiologie und Intensivmedizin, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Deutschland, christian.fuchs@uni-greifswald.de.

Der Anaesthesist
|February 27, 2014
PubMed
Summary
This summary is machine-generated.

Overwhelming postsplenectomy infection syndrome (OPSI) poses a high mortality risk, especially for patients with hematological diseases. Immediate sepsis therapy and antibiotic prophylaxis are crucial for at-risk individuals lacking adequate antibody response post-splenectomy.

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Area of Science:

  • Infectious Diseases
  • Hematology
  • Immunology

Background:

  • Overwhelming postsplenectomy infection syndrome (OPSI) is a severe sepsis with high mortality, primarily caused by Streptococcus pneumoniae.
  • Patients who have undergone splenectomy for hematological diseases are at increased risk of OPSI.

Observation:

  • A significant percentage of patients (20-30%) with splenectomy for hematological conditions do not achieve adequate antibody response after recommended Streptococcus pneumoniae immunization.
  • This underscores a critical vulnerability in a specific patient population.

Findings:

  • The study highlights the persistent risk of fulminant sepsis in asplenic individuals, particularly those with hematological disorders.
  • Inadequate immune response to pneumococcal vaccination is a key factor contributing to this heightened risk.

Implications:

  • Patients with a history of splenectomy for hematological diseases require specialized education on fever management and immediate sepsis recognition.
  • Proactive antibiotic prophylaxis and prompt sepsis therapy are essential to mitigate the high mortality associated with OPSI in this vulnerable group.