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Percutaneous coronary intervention in a case of afibrinogenemia

Homa Falsoleiman1, Mehdi Hasanzadeh Daloee, Mashalla Dehghani

  • 1Mashhad Cardiac Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Asian Cardiovascular & Thoracic Annals
|February 27, 2014
PubMed

Insights

Congenital afibrinogenemia, a rare blood disorder, poses unique challenges in managing acute myocardial infarction. Successful percutaneous coronary intervention with a bare metal stent was achieved in a patient with this condition.

Area of Science:

  • Cardiology
  • Hematology
  • Genetics

Background:

  • Congenital afibrinogenemia is a rare autosomal recessive disorder characterized by a complete absence of fibrinogen.
  • Patients with congenital afibrinogenemia have a bleeding diathesis, making thrombotic events rare but management complex.

Observation:

  • A 30-year-old female with known congenital afibrinogenemia presented with acute anterior myocardial infarction.
  • Initial medical management with dual antiplatelet therapy and atorvastatin was insufficient to relieve her chest pain.

Findings:

  • The patient underwent successful percutaneous coronary intervention (PCI) of a proximal left anterior descending artery occlusion.
  • A bare metal stent was deployed, leading to complete resolution of ischemic symptoms.

Implications:

  • This case highlights the feasibility of successful PCI in patients with congenital afibrinogenemia.
  • Careful consideration of antiplatelet strategies and stent selection is crucial for managing thrombotic events in afibrinogenemia patients.

Keywords:
Afibrinogenemiaangioplastyblood coagulation disordersinheritedmyocardial infarctionstents

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