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4,5-Dihydropyrrolo[1,2-a]quinoxalines: a tunable and regenerable biomimetic hydrogen source
Zhang-Pei Chen1, Mu-Wang Chen, Ran-Ning Guo
1State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, China .
Organic Letters
|February 28, 2014
Abstract:
A series of tunable and regenerable biomimetic hydrogen sources, 4,5-dihydropyrrolo[1,2-a]quinoxalines, have been synthesized and applied in biomimetic asymmetric hydrogenation of 3-aryl-2H-benzo[b][1,4]oxazines and 1-alkyl-3-aryl-quinoxalin-2(1H)-ones, providing the chiral amines with up to 92% and 89% ee, respectively.
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