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Updated: May 2, 2026

Covalent Binding of Antibodies to Cellulose Paper Discs and Their Applications in Naked-eye Colorimetric Immunoassays
Published on: October 21, 2016
Cellulose paper sensors modified with zwitterionic poly(carboxybetaine) for sensing and detection in complex media
Yongheng Zhu1, Xuewei Xu, Norman D Brault
1Department of Chemical Engineering, University of Washington , Seattle, Washington 98195, United States.
Abstract:
Poly(carboxybetaine) (PCB) functionalized cellulose paper was used as a paper-based microfluidic device. The results showed that the PCB modified paper sensor was able to achieve (a) more rapid and sensitive glucose detection from undiluted human serum compared to bare cellulose and (b) specific antigen detection via covalently immobilized antibodies.
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