Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

25
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
25
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: Toward adaptive radiotherapy for lung patients: feasibility study on deforming planning CT to CBCT to assess the impact of anatomical changes on dosimetry (A J Cole<i>et al</i>2018<i>Phys. Med. Biol</i>.<b>63</b>155014).

Physics in medicine and biology·2026
Same author

The Association of Incidental Radiation Dose to the Heart Base with Overall Survival and Cardiac Events after Curative-intent Radiotherapy for Non-small Cell Lung Cancer: Results from the NI-HEART Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023
Same author

Immunoglobulins in systemic sclerosis management. A large multicenter experience.

Autoimmunity reviews·2023
Same author

Impact of previous glucocorticoid therapy on diagnostic accuracy of [18F] FDG PET-CT in giant cell arteritis.

Seminars in arthritis and rheumatism·2023
Same author

Radiomics for Predicting Lung Cancer Outcomes Following Radiotherapy: A Systematic Review.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

Local Control: Also a Strength of Radiotherapy Training?

Clinical oncology (Royal College of Radiologists (Great Britain))·2021

Related Experiment Video

Updated: May 2, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

5.3K

Spine injuries in runners: A functional approach.

A J Cole1, S A Herring2, S A Stratton3

  • 1Tom Landry Sports Medicine and Research Center, Department of Physical Medicine and Rehabilitation, 411 N. Washington, Suite 4000, LB 10, Dallas, Texas 75246, USA Department of Physical Medicine and Rehabilitation and Department of Physical Therapy, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Journal of Back and Musculoskeletal Rehabilitation
|February 28, 2014
PubMed
Summary

Running increases the risk of lumbar spine injuries, which can be debilitating. Early diagnosis and a phased rehabilitation plan focusing on biomechanics and neuromuscular control are crucial for recovery and preventing recurrence.

Keywords:
BiomechanicsInjuriesRehabilitationRunningSpine

More Related Videos

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats
06:40

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Published on: January 16, 2019

9.4K
An Inertial Measurement Unit Based Method to Estimate Hip and Knee Joint Kinematics in Team Sport Athletes on the Field
06:52

An Inertial Measurement Unit Based Method to Estimate Hip and Knee Joint Kinematics in Team Sport Athletes on the Field

Published on: May 26, 2020

10.1K

Related Experiment Videos

Last Updated: May 2, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

5.3K
Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats
06:40

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Published on: January 16, 2019

9.4K
An Inertial Measurement Unit Based Method to Estimate Hip and Knee Joint Kinematics in Team Sport Athletes on the Field
06:52

An Inertial Measurement Unit Based Method to Estimate Hip and Knee Joint Kinematics in Team Sport Athletes on the Field

Published on: May 26, 2020

10.1K

Area of Science:

  • Sports Medicine
  • Biomechanics
  • Rehabilitation Science

Background:

  • Running participation has surged, leading to a rise in associated injuries.
  • Lumbar spine injuries, though less common, are particularly debilitating for runners.
  • Running biomechanics involve complex kinetic chain interactions impacting the lumbar spine.

Purpose of the Study:

  • To explore the multifactorial etiology of running-related lumbar spine injuries.
  • To highlight the importance of accurate diagnosis and comprehensive rehabilitation.
  • To outline a phased approach to managing lumbar spine injuries in runners.

Main Methods:

  • Review of biomechanical principles of the lower extremity kinetic chain during running.
  • Analysis of factors contributing to lumbar spine stress and dysfunction.
  • Description of rehabilitation strategies for acute and subacute phases.

Main Results:

  • Dysfunction in the kinetic chain can lead to cascading adaptations in the lumbar spine.
  • Running alters lumbar spine biomechanics, affecting tissue function (strength, flexibility, proprioception).
  • A phased rehabilitation approach is essential for addressing injury and preventing recurrence.

Conclusions:

  • Accurate diagnosis is critical for effective rehabilitation of lumbar spine injuries in runners.
  • Rehabilitation should address biomechanical deficits, strength, endurance, and proprioception.
  • Running-specific exercises can be integrated early in the subacute phase.