Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

395
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
395
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

861
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
861
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

382
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
382
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

354
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
354
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

400
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
400

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of Stages of Objective Memory Impairment with Cerebrospinal Fluid and Neuroimaging Biomarkers of Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2023
Same author

Parkinson's disease: Evolution of the scientific literature from 1983 to 2017 by countries and journals.

Parkinsonism & related disorders·2018
Same author

The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility.

The journal of headache and pain·2018
Same author

The Headache-Attributed Lost Time (HALT) Indices: measures of burden for clinical management and population-based research.

The journal of headache and pain·2018
Same author

Increased pain sensitivity in migraine and tension-type headache coexistent with low back pain: A cross-sectional population study.

European journal of pain (London, England)·2018
Same author

Neuroticism, depression and pain perception in migraine and tension-type headache.

Acta neurologica Scandinavica·2017
Same journal

Psychometrics properties of self-reported pain sensitivity measures in individuals with shoulder pain.

Journal of back and musculoskeletal rehabilitation·2026
Same journal

The evolution of ultrasound in sarcopenia assessment: Global trends, technological shifts, and clinical frontiers.

Journal of back and musculoskeletal rehabilitation·2026
Same journal

Variability and influencing factors of posterior condylar offset in posterior-stabilized total knee arthroplasty.

Journal of back and musculoskeletal rehabilitation·2026
Same journal

Short-term effects of kinesiology taping, dry needling and their combination in patients with subacromial pain syndrome: A single-blind randomized controlled trial.

Journal of back and musculoskeletal rehabilitation·2026
Same journal

Associations between musculoskeletal health literacy and changes in pain catastrophizing and kinesiophobia after arthroscopic rotator cuff repair: A prospective study.

Journal of back and musculoskeletal rehabilitation·2026
Same journal

Relationship between hamstring flexibility (askling H-test) and isokinetic strength ratios in elite soccer players with prior hamstring strain injury: A cross-sectional study.

Journal of back and musculoskeletal rehabilitation·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K

Headache in the elderly.

W B Young1, S D Silberstein1, R B Lipton2

  • 1Department of Neurology, Jefferson Headache Center, 111 South 11th Street, Ste. 8130, Philadelphia, PA 19107-5092, USA.

Journal of Back and Musculoskeletal Rehabilitation
|February 28, 2014
PubMed
Summary
This summary is machine-generated.

Headaches in older adults often signal serious conditions, necessitating prompt medical evaluation. New or changed headaches after age 55 require ruling out secondary causes like tumors or stroke.

Keywords:
ElderlyEpidemiologyHeadache

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

8.6K
Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

12.4K

Related Experiment Videos

Last Updated: May 2, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

8.6K
Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

12.4K

Area of Science:

  • Neurology
  • Geriatrics

Background:

  • Headache prevalence shifts with age, with primary disorders decreasing and secondary causes increasing.
  • New-onset or altered headache patterns in individuals over 55 warrant careful consideration of serious underlying conditions.

Purpose of the Study:

  • To review secondary causes of headache in the elderly.
  • To discuss symptoms, diagnostic testing, and treatment for headaches in older patients.
  • To cover the epidemiology and management of primary headache disorders in this demographic.

Main Methods:

  • Literature review focusing on secondary headaches in the elderly.
  • Analysis of diagnostic approaches and treatment strategies.
  • Epidemiological review of primary headache disorders in older adults.

Main Results:

  • Headaches beginning after age 55 are frequently linked to severe conditions or comorbidities.
  • Serious secondary causes include tumors, subdural hematomas, stroke, transient ischemic attacks, and temporal arteritis.
  • A lower threshold for diagnostic testing is advised for new, atypical, or neurologically associated headaches in the elderly.

Conclusions:

  • Prompt identification and management of secondary headaches are crucial in older patients.
  • Thorough evaluation, including appropriate testing, is essential for new or changed headaches in the elderly.
  • Understanding both primary and secondary headache etiologies is key for effective geriatric headache care.