Modification of biomaterials with a self-protein inhibits the macrophage response
Yoon Kyung Kim1, Richard Que, Szu-Wen Wang
1Department of Biomedical Engineering, University of California, Irvine, 2412 Engineering Hall, Irvine, CA, 92697-2730, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, CA, 92697-2730, USA.
Advanced Healthcare Materials
|February 28, 2014
Abstract:
A biomaterial inhibits the host immune response by displaying an endo-genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.
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