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Related Experiment Video

Updated: May 2, 2026

Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics
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Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics

Published on: May 28, 2016

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Chemically orthogonal three-patch microparticles.

Sahar Rahmani1, Sampa Saha, Hakan Durmaz

  • 1Department of Biomedical Engineering, Chemical Engineering, Macromolecular Science and Engineering, Material Science and Engineering, University of Michigan, Ann Arbor, 48109 (USA) http://www.umich.edu/∼lahannj/index.htm; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany).

Angewandte Chemie (International Ed. in English)
|February 28, 2014
PubMed
Summary
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Researchers developed novel two- and three-patch microparticles using electrohydrodynamic co-jetting. This method allows precise spatial control for creating multifunctional particles with distinct surface anchor groups for advanced applications.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Microfluidics

Background:

  • Limited methods exist for spatially controlled surface modification of 3D objects like microparticles.
  • Multifunctional microparticles are crucial for applications requiring directional presentation of multiple ligands.

Purpose of the Study:

  • To develop a novel methodology for creating spatially controlled, multifunctional microparticles.
  • To demonstrate the fabrication of two- and three-patch microparticles with chemically orthogonal anchor groups.

Main Methods:

  • Combined electrohydrodynamic co-jetting with synthetic polymer chemistry.
  • Utilized novel chemically orthogonal polylactide-based polymers.
  • Fabricated micropatterned particles with distinct surface patches.
Keywords:
click chemistryelectrohydrodynamic co-jettingmicroparticlesorthogonal chemistrysurface chemistry

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Main Results:

  • Successfully created two- and three-patch microparticles with precise spatial control.
  • Demonstrated the presence of chemically orthogonal anchor groups on distinct surface patches.
  • Achieved orthogonal click functionalities on the synthesized microparticles.

Conclusions:

  • Established a viable route for orthogonal reaction strategies on multivalent micropatterned particles.
  • The developed approach yields unprecedented multifunctional microparticles for diverse applications.
  • This technique offers a significant advancement in the controlled surface decoration of 3D microstructures.