Related Experiment Videos
Paraoxon-induced desensitization and its reversal by tetrodotoxin
A L Gardner1, L K Choo, F Mitchelson
1School of Pharmacology, Victorian College of Pharmacy, Melbourne, Australia.
General Pharmacology
|January 1, 1988
Abstract:
1. Paraoxon (10 microM for 20 min) induced a desensitization of the taenia caecum of the guinea-pig for contractions produced by a number of cholinomimetics. 2. Tetrodotoxin (0.3 microM) reversed the desensitization suggesting involvement of Na+ channels.