[Risk factors and prognosis of liver metastasis from gastric cancer]

Liver metastasis from gastric cancer is a major cause of cancer-related death. Since liver metastasis from gastric cancer is usually associated with other non-curative factors, such as peritoneal metastasis, lymph node metastasis and extensive intrahepatic metastasis, the hepatic resection rate was low and the prognosis was poor. The main risk factors of liver metastasis were serosal invasion, p(+), N3-N4, differentiated histologic type, medullary type of poorly differentiated adenocarcinoma, vascular invasion, and overexpression and mutation of VEGF, P53 and c-erbb-2. The 5-year survival rate after hepatic resection of synchronous and metachronous liver metastasis from gastric cancer ranged from 11% to 42%. Appropriate patient selection for hepatic resection may confer a better prognosis of liver metastasis from gastric cancer.