Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.2K

Tumor-targeting multifunctional nanoparticles for siRNA delivery: recent advances in cancer therapy

Sook Hee Ku1, Kwangmeyung Kim, Kuiwon Choi

  • 1Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 136-791, Republic of Korea.

Advanced Healthcare Materials
|March 1, 2014
PubMed

Insights

Small interfering RNA (siRNA) holds promise for cancer therapy by silencing genes. Nanocarriers are being developed to protect siRNA and improve its delivery for enhanced antitumor effects.

Area of Science:

  • Biotechnology and Nanomedicine
  • Molecular Biology and Genetics
  • Cancer Therapeutics

Background:

  • RNA interference (RNAi) is a natural gene regulatory process.
  • Small interfering RNA (siRNA) therapeutics offer potential for cancer treatment by silencing disease-related genes.
  • Clinical use of siRNA is hindered by degradation and inefficient delivery.

Purpose of the Study:

  • To review recent advancements in siRNA nanocarriers for cancer therapy.
  • To summarize nanoparticle systems and their antitumor effects.
  • To discuss multifunctional nanocarriers for theranostics and combinatorial therapy.

Main Methods:

  • Review of current literature on siRNA nanocarrier systems.
  • Analysis of various nanoparticle designs for siRNA delivery.
  • Summary of studies evaluating antitumor efficacy of siRNA nanocarriers.

Main Results:

  • Development of novel nanocarriers enhances siRNA stability and cellular uptake.
  • Targeted nanocarriers demonstrate significant antitumor effects in preclinical models.
  • Emerging multifunctional nanocarriers show potential for combined diagnostics and therapeutics.

Conclusions:

  • SiRNA nanocarriers represent a promising strategy to overcome delivery challenges in RNAi-based cancer therapy.
  • Continued development of tumor-targeting and multifunctional nanocarriers is crucial for clinical translation.
  • These advanced systems offer new avenues for personalized cancer treatment.
Keywords:
cancer therapymultifunctional nanoparticlessiRNA deliverytumor targeting

More Related Videos

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

7.1K
Porous Silicon Microparticles for Delivery of siRNA Therapeutics08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

10.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.5K