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Published on: September 2, 2025
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Pathological site retargeting under tissue deformation using geometrical association and tracking
Menglong Ye1, Stamatia Giannarou2, Nisha Patel2
1The Hamlyn Centre for Robotic Surgery, Department of Surgery and Cancer, Imperial College London, UK. menglong.ye11@imperial.ac.uk
Summary
This study introduces a new method for precisely tracking pathological sites during endoscopic examinations. This technique ensures accurate retargeting for follow-up examinations, improving early disease detection and management.
Area of Science:
- Medical Imaging
- Gastroenterology
- Optical Diagnostics
Background:
- Advanced microscopic detection techniques like fluorescence spectroscopy, confocal microscopy, and optical coherence tomography aid in early disease detection during endoscopy.
- Optical-based biopsies eliminate the need for traditional histopathological samples and off-line analysis.
- Accurate tracking of biopsy sites is crucial for retargeting and serial examinations, as optical sampling leaves no visible marks.
Purpose of the Study:
- To propose a novel approach for pathological site retargeting in gastroscopic examinations.
- To enable precise online, in vivo tracking of diseased tissues during endoscopic procedures.
- To enhance the reliability of serial examinations for early-stage disease detection.
Main Methods:
- The proposed method utilizes affine deformation modeling and geometrical association.
- It incorporates cascaded online learning and tracking algorithms.
- The approach is designed to be robust to tissue deformation and partial occlusions.
Main Results:
- The method provides online, in vivo retargeting of pathological sites.
- It successfully tracks sites despite significant tissue deformation.
- The system demonstrates robustness against partial occlusions during examination.
Conclusions:
- The developed pathological site retargeting method is effective for gastroscopic examinations.
- It supports accurate follow-up examinations by enabling precise site localization.
- The approach is versatile and compatible with various imaging probes, including confocal laser endomicroscopy.

